Mutations in Main Protease of SARS CoV-2 Decreased Boceprevir Affinity
نویسندگان
چکیده
HIGHLIGHTS Boceprevir is a potential therapeutic that targets the main protease of SARS-CoV-2. Mutations change inhibitory binding pattern in catalytic domain protease. SARS-CoV-2 cause decrease boceprevir affinity.
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ژورنال
عنوان ژورنال: Brazilian Archives of Biology and Technology
سال: 2021
ISSN: ['1678-4324', '1516-8913']
DOI: https://doi.org/10.1590/1678-4324-2021200803